Version 5.4
Homo sapiens Protein: GLT25D1
Summary
InnateDB Protein IDBP-36910.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLT25D1
Protein Name glycosyltransferase 25 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252599
InnateDB Gene IDBG-36908 (GLT25D1)
Protein Structure
UniProt Annotation
Function Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen. {ECO:0000269PubMed:19075007}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:20470363}. Note=Colocalized with PLOD3 and mannose binding lectin.
Disease Associations
Tissue Specificity Ubiquitous with higher levels in placenta, heart, lung and spleen. {ECO:0000269PubMed:19075007}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0050211 procollagen galactosyltransferase activity
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002654 Glycosyl transferase, family 25
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF01755
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBJ5
PhosphoSite PhosphoSite-Q8NBJ5
TrEMBL Q8WUI9
UniProt Splice Variant
Entrez Gene 79709
UniGene Hs.625887
RefSeq NP_078932
HUGO HGNC:26182
OMIM
CCDS CCDS12363
HPRD 07986
IMGT
EMBL AC010618 AK057140 AK074941 AK075541 BC020492 BC108308 CH471106
GenPept AAH20492 AAI08309 BAC11307 BAC11684 BAG51872 EAW84622

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca