Version 5.4
Homo sapiens Protein: LPAR4
Summary
InnateDB Protein IDBP-369363.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPAR4
Protein Name lysophosphatidic acid receptor 4
Synonyms GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9;
Species Homo sapiens
Ensembl Protein ENSP00000408205
InnateDB Gene IDBG-78052 (LPAR4)
Protein Structure
UniProt Annotation
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA. {ECO:0000269PubMed:12724320}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus. {ECO:0000269PubMed:12724320}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008289 lipid binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99677
PhosphoSite PhosphoSite-
TrEMBL V9GY74
UniProt Splice Variant
Entrez Gene 2846
UniGene Hs.522701
RefSeq NP_005287
HUGO HGNC:4478
OMIM 300086
CCDS CCDS14441
HPRD 02099
IMGT
EMBL AF005419 AK314134 AL590083 AY301274 BC069996 BC074722 BC095538 CH471104 U66578 U90322 U90323
GenPept AAB62087 AAB62088 AAB66322 AAC51301 AAH69996 AAH74722 AAH95538 AAP58404 BAG36824 CAD18851 EAW98596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca