Version 5.4
Homo sapiens Protein: AMBN
Summary
InnateDB Protein IDBP-369771.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMBN
Protein Name ameloblastin (enamel matrix protein)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000391234
InnateDB Gene IDBG-22555 (AMBN)
Protein Structure
UniProt Annotation
Function Involved in the mineralization and structural organization of enamel.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0030345 structural constituent of tooth enamel
Biological Process
GO:0007155 cell adhesion
GO:0008283 cell proliferation
GO:0031214 biomineral tissue development
GO:0042475 odontogenesis of dentin-containing tooth
Cellular Component
GO:0005578 proteinaceous extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR007798 Ameloblastin precursor
PFAM PF05111
PRINTS
PIRSF
SMART SM00817
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP70
PhosphoSite PhosphoSite-Q9NP70
TrEMBL
UniProt Splice Variant
Entrez Gene 258
UniGene Hs.272396
RefSeq
HUGO HGNC:452
OMIM 601259
CCDS
HPRD 03160
IMGT
EMBL AF209780 AF219994 AF263464 AY009116 AY009117 AY009118 AY009119 AY009120 AY009121 AY009122 AY009123 AY009124 BC106931
GenPept AAF37355 AAF73048 AAG27036 AAG35772 AAI06932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca