InnateDB Protein
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IDBP-370172.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBP1
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Protein Name
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upstream binding protein 1 (LBP-1a)
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Synonyms
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LBP-1a; LBP-1B; LBP1A; LBP1B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000395558
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InnateDB Gene
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IDBG-24132 (UBP1)
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Protein Structure
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Function |
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269PubMed:10644752, ECO:0000269PubMed:2006421, ECO:0000269PubMed:8114710}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:8114710}.
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Disease Associations |
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Tissue Specificity |
Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines. {ECO:0000269PubMed:10644752}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003714
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transcription corepressor activity
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0019079
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viral genome replication
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR007604
CP2 transcription factor
IPR013761
Sterile alpha motif/pointed domain
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PFAM |
PF04516
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NZI7
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PhosphoSite |
PhosphoSite-Q9NZI7
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TrEMBL |
C9JWL3
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UniProt Splice Variant |
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Entrez Gene |
7342
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UniGene |
Hs.729120
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RefSeq |
NP_001121632
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HUGO |
HGNC:12507
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OMIM |
609784
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CCDS |
CCDS46788
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HPRD |
10291
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IMGT |
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EMBL |
AC093114
AC122176
AF198487
AK023274
BC047235
CH471055
CR749798
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GenPept |
AAF32274
AAH47235
BAB14501
CAH18658
EAW64456
EAW64457
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