InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEDD8

Summary

InnateDB Protein

IDBP-3702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEDD8

Protein Name

neural precursor cell expressed, developmentally down-regulated 8

Synonyms

NEDD-8;

Species

Homo sapiens

Ensembl Protein

ENSP00000250495

InnateDB Gene

IDBG-3700 (NEDD8)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. {ECO:0000269PubMed:10318914, ECO:0000269PubMed:10597293, ECO:0000269PubMed:11953428}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9353319}. Note=Mainly nuclear.

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269PubMed:10597293, ECO:0000269PubMed:9353319}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 793 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	793 [view]
Protein-Protein	791 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008104	protein localization
GO:0009653	anatomical structure morphogenesis
GO:0014070	response to organic cyclic compound
GO:0045116	protein neddylation