InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP1S

Summary

InnateDB Protein

IDBP-37024.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP1S

Protein Name

microtubule-associated protein 1S

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325313

InnateDB Gene

IDBG-37022 (MAP1S)

Protein Structure

UniProt Annotation

Function

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle. {ECO:0000269PubMed:11827465, ECO:0000269PubMed:14627543, ECO:0000269PubMed:17658481}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0042802	identical protein binding
GO:0048487	beta-tubulin binding
GO:0051015	actin filament binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0006309	apoptotic DNA fragmentation
GO:0007399	nervous system development
GO:0007420	brain development
GO:0047497	mitochondrion transport along microtubule
GO:0048812	neuron projection morphogenesis
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0030054	cell junction
GO:0030425	dendrite
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm