Homo sapiens Protein: CHRAC1
Summary
InnateDB Protein IDBP-37073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRAC1
Protein Name chromatin accessibility complex 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000220913
InnateDB Gene IDBG-37071 (CHRAC1)
Protein Structure
UniProt Annotation
Function Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006338 chromatin remodeling
Cellular Component
GO:0005622 intracellular
GO:0008622 epsilon DNA polymerase complex
GO:0008623 CHRAC
Protein Structure and Domains
PDB ID
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR009072 Histone-fold
PFAM PF00808
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRG0
PhosphoSite PhosphoSite-Q9NRG0
TrEMBL
UniProt Splice Variant
Entrez Gene 54108
UniGene Hs.598227
RefSeq NP_059140
HUGO HGNC:13544
OMIM 607268
CCDS CCDS6379
HPRD 06275
IMGT
EMBL AF226076 AK023537 BC015891
GenPept AAF72416 AAH15891 BAB14601