InnateDB Protein
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IDBP-370825.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HYPK
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Protein Name
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chromosome 15 open reading frame 63
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Synonyms
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C15orf63;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000401155
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InnateDB Gene
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IDBG-402223 (HYPK)
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Protein Structure
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Function |
Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation. {ECO:0000269PubMed:17947297, ECO:0000269PubMed:20154145}.
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Subcellular Localization |
Nucleus. Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NX55
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PhosphoSite |
PhosphoSite-Q9NX55
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TrEMBL |
A0A024R5Q1
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UniProt Splice Variant |
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Entrez Gene |
25764
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UniGene |
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RefSeq |
NP_057484
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HUGO |
HGNC:18418
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OMIM |
612784
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CCDS |
CCDS10104
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HPRD |
13724
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IMGT |
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EMBL |
AC018512
AF049613
AF161485
AK000438
AK022435
BC019262
CH471082
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GenPept |
AAC26849
AAF29100
AAH19262
BAA91165
EAW77241
EAW77242
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