InnateDB Protein
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IDBP-37088.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FCHO1
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Protein Name
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FCH domain only 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000252771
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InnateDB Gene
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IDBG-37086 (FCHO1)
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Protein Structure
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Function |
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269PubMed:20448150}.
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Subcellular Localization |
Membrane, clathrin-coated pit {ECO:0000305PubMed:17617719, ECO:0000305PubMed:20448150}; Peripheral membrane protein {ECO:0000305PubMed:17617719, ECO:0000305PubMed:20448150}; Cytoplasmic side {ECO:0000305PubMed:17617719, ECO:0000305PubMed:20448150}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001060
FCH domain
IPR018808
Muniscin C-terminal
IPR028565
Mu homology domain
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PFAM |
PF00611
PF10291
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PRINTS |
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PIRSF |
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SMART |
SM00055
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TIGRFAMs |
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Modification |
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SwissProt |
O14526
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PhosphoSite |
PhosphoSite-O14526
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TrEMBL |
M0R3E5
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UniProt Splice Variant |
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Entrez Gene |
23149
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UniGene |
Hs.96485
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RefSeq |
XP_005259888
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HUGO |
HGNC:29002
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OMIM |
613437
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CCDS |
CCDS32955
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HPRD |
16887
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IMGT |
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EMBL |
AB006628
AC008761
AK291410
AK303623
BC028021
BC041130
CH471106
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GenPept |
AAH28021
AAH41130
BAA22959
BAF84099
BAG64632
EAW84629
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