InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMO2

Summary

InnateDB Protein

IDBP-370977.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMO2

Protein Name

LIM domain only 2 (rhombotin-like 1)

Synonyms

RBTN2; RBTNL1; RHOM2; TTG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000401967

InnateDB Gene

IDBG-38928 (LMO2)

Protein Structure

UniProt Annotation

Function

Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	53 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043425	bHLH transcription factor binding
GO:0048037	cofactor binding
GO:0070888	E-box binding

Biological Process

GO:0007275	multicellular organismal development
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097067	cellular response to thyroid hormone stimulus