Version 5.4
Homo sapiens Protein: PENK
Summary
InnateDB Protein IDBP-371009.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PENK
Protein Name proenkephalin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400894
InnateDB Gene IDBG-22561 (PENK)
Protein Structure
UniProt Annotation
Function Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000703 Proenkephalin A
IPR006024 Opioid neuropeptide precursor
PFAM PF01160
PRINTS PR01029
PR01028
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01210
PhosphoSite PhosphoSite-P01210
TrEMBL E5RFR1
UniProt Splice Variant
Entrez Gene 5179
UniGene Hs.733358
RefSeq NP_001129162
HUGO HGNC:8831
OMIM 131330
CCDS CCDS6168
HPRD 08837
IMGT
EMBL AC023464 AK314908 BC032505 CH471068 CR541808 CR541828 J00122 J00123 V00509
GenPept AAB59409 AAH32505 BAG37420 CAA23767 CAG46607 CAG46627 EAW86785 EAW86787

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca