Version 5.4
Homo sapiens Protein: COMMD7
Summary
InnateDB Protein IDBP-371158.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COMMD7
Protein Name COMM domain containing 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000395339
InnateDB Gene IDBG-65365 (COMMD7)
Protein Structure
UniProt Annotation
Function Associates with the NF-kappa-B complex and suppresses its transcriptional activity. {ECO:0000269PubMed:15799966}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed with highest expression in lung. {ECO:0000269PubMed:15799966}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009886 HCaRG
PFAM PF07258
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VX2
PhosphoSite PhosphoSite-Q86VX2
TrEMBL
UniProt Splice Variant
Entrez Gene 149951
UniGene Hs.408427
RefSeq NP_001092809
HUGO HGNC:16223
OMIM
CCDS CCDS46587
HPRD 13085
IMGT
EMBL AK027893 AK096307 AL035071 AY542162 BC000628 BC047440 BI821799 BX640505 CH471077 FO393400
GenPept AAH00628 AAH47440 AAS22244 BAB55436 BAG53254 EAW76360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca