InnateDB Protein
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IDBP-371170.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LRRFIP2
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Protein Name
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leucine rich repeat (in FLII) interacting protein 2
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Synonyms
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HUFI-2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000416364
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InnateDB Gene
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IDBG-24724 (LRRFIP2)
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Protein Structure
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Function |
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269PubMed:15677333, ECO:0000269PubMed:19265123}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269PubMed:10366446}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009053
Prefoldin
IPR019139
Leucine-rich repeat flightless-interacting protein
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PFAM |
PF09738
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y608
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PhosphoSite |
PhosphoSite-Q9Y608
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TrEMBL |
C9JSU1
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UniProt Splice Variant |
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Entrez Gene |
9209
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UniGene |
Hs.740522
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RefSeq |
NP_001127841
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HUGO |
HGNC:6703
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OMIM |
614043
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CCDS |
CCDS46791
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HPRD |
10061
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IMGT |
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EMBL |
AC006583
AC126118
AF115509
AK000255
AK291514
BC053668
CR749705
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GenPept |
AAD41257
AAH53668
BAA91035
BAF84203
CAH18481
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