InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYD88

Summary

InnateDB Protein

IDBP-371953.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYD88

Protein Name

myeloid differentiation primary response gene (88)

Synonyms

MYD88D;

Species

Homo sapiens

Ensembl Protein

ENSP00000391753

InnateDB Gene

IDBG-25713 (MYD88)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	120 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070976	TIR domain binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0007165	signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000488 Death domain
IPR011029 Death-like domain
IPR017281 Myeloid differentiation primary response protein MyD88

PFAM

PF01582
PF13676
PF00531

PRINTS

PIRSF

PIRSF037756

SMART

SM00255
SM00005

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt