InnateDB Protein
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IDBP-372241.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM205
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Protein Name
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transmembrane protein 205
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398258
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InnateDB Gene
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IDBG-29156 (TMEM205)
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Protein Structure
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Function |
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. {ECO:0000269PubMed:20589834}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:20589834}; Multi-pass membrane protein {ECO:0000269PubMed:20589834}. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level). {ECO:0000269PubMed:20589834}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UW68
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PhosphoSite |
PhosphoSite-Q6UW68
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TrEMBL |
K7ER05
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UniProt Splice Variant |
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Entrez Gene |
374882
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UniGene |
Hs.8036
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RefSeq |
NP_212133
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HUGO |
HGNC:29631
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OMIM |
613771
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CCDS |
CCDS32909
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HPRD |
18605
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IMGT |
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EMBL |
AC024575
AK291979
AY358949
BC064948
BC091472
CH471106
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GenPept |
AAH64948
AAH91472
AAQ89308
BAF84668
EAW84191
EAW84192
EAW84193
EAW84197
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