InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELAVL3

Summary

InnateDB Protein

IDBP-372418.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELAVL3

Protein Name

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

Synonyms

HUC; HUCL; PLE21;

Species

Homo sapiens

Ensembl Protein

ENSP00000390878

InnateDB Gene

IDBG-29474 (ELAVL3)

Protein Structure

UniProt Annotation

Function

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance. {ECO:0000250, ECO:0000269PubMed:10710437}.

Subcellular Localization

Disease Associations

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0017091	AU-rich element binding

Biological Process

GO:0007399	nervous system development
GO:0030154	cell differentiation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002343 Paraneoplastic encephalomyelitis antigen
IPR003954 RNA recognition motif domain, eukaryote
IPR006548 Splicing factor ELAV/HuD

PFAM

PF00076

PRINTS

PR00961

PIRSF

SMART

SM00360
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt