InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFRP4

Summary

InnateDB Protein

IDBP-372443.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP4

Protein Name

secreted frizzled-related protein 4

Synonyms

FRP-4; FRPHE; sFRP-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000410715

InnateDB Gene

IDBG-12815 (SFRP4)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.

Disease Associations

Tissue Specificity

Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269PubMed:10728394, ECO:0000269PubMed:19480240}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0002092	positive regulation of receptor internalization
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0009725	response to hormone
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0022601	menstrual cycle phase
GO:0043065	positive regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606	positive regulation of epidermal cell differentiation
GO:0046329	negative regulation of JNK cascade
GO:0046697	decidualization
GO:0055062	phosphate ion homeostasis
GO:0060056	mammary gland involution
GO:0060429	epithelium development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:2000119	negative regulation of sodium-dependent phosphate transport

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6FHJ7