InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCN10A

Summary

InnateDB Protein

IDBP-372449.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN10A

Protein Name

sodium channel, voltage-gated, type X, alpha subunit

Synonyms

FEPS2; hPN3; Nav1.8; PN3; SNS;

Species

Homo sapiens

Ensembl Protein

ENSP00000390600

InnateDB Gene

IDBG-26173 (SCN10A)

Protein Structure

UniProt Annotation

Function

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269PubMed:9839820}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=It can be translocated to the extracellular membrane through association with S100A10. {ECO:0000250}.

Disease Associations

Episodic pain syndrome, familial, 2 (FEPS2) [MIM:615551]: An autosomal dominant neurologic disorder characterized by adult- onset of paroxysmal pain mainly affecting the distal lower extremities. {ECO:0000269PubMed:23115331}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in the dorsal root ganglia and sciatic nerve. {ECO:0000269PubMed:9839820}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity

Biological Process

GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007600	sensory perception
GO:0019228	neuronal action potential
GO:0019233	sensory perception of pain
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0086010	membrane depolarization during action potential
GO:0086067	AV node cell to bundle of His cell communication
GO:0086069	bundle of His cell to Purkinje myocyte communication

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0044299	C-fiber
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF00520
PF06512
PF08016

PRINTS

PR00170
PR01433

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5Y9