InnateDB Protein
|
IDBP-372466.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PAPD4
|
Protein Name
|
PAP associated domain containing 4
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000396861
|
InnateDB Gene
|
IDBG-31087 (PAPD4)
|
Protein Structure
|
|
Function |
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla. {ECO:0000269PubMed:15987818}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002058
PAP/25A-associated
|
PFAM |
PF03828
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6PIY7
|
PhosphoSite |
PhosphoSite-Q6PIY7
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
167153
|
UniGene |
Hs.607229
|
RefSeq |
|
HUGO |
HGNC:26776
|
OMIM |
614121
|
CCDS |
CCDS4048
|
HPRD |
15098
|
IMGT |
|
EMBL |
AK095818
BC026061
BC047581
CH471084
|
GenPept |
AAH26061
AAH47581
BAC04629
EAW95837
|
|
|