InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CMYA5

Summary

InnateDB Protein

IDBP-372505.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMYA5

Protein Name

cardiomyopathy associated 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000394770

InnateDB Gene

IDBG-31138 (CMYA5)

Protein Structure

UniProt Annotation

Function

May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269PubMed:20634290}. Note=Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z-disks. Occasionnally present at the M-band level. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle; at a strong level and in heart. {ECO:0000269PubMed:11297942}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0014733	regulation of skeletal muscle adaptation
GO:0032513	negative regulation of protein phosphatase type 2B activity
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade