Version 5.4
Homo sapiens Protein: EIF2AK2
Summary
InnateDB Protein IDBP-372514.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2AK2
Protein Name eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms EIF2AK1; PKR; PPP1R83; PRKR;
Species Homo sapiens
Ensembl Protein ENSP00000393921
InnateDB Gene IDBG-44867 (EIF2AK2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 134 [view]
Protein-Protein 120 [view]
Protein-DNA 10 [view]
Protein-RNA 2 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR014720 Double-stranded RNA-binding domain
PFAM PF00035
PRINTS
PIRSF
SMART SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F8WBH4
UniProt Splice Variant
Entrez Gene 5610
UniGene Hs.738069
RefSeq
HUGO HGNC:9437
OMIM 176871
CCDS
HPRD 01468
IMGT
EMBL AC007899
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca