Version 5.4
Homo sapiens Protein: F2
Summary
InnateDB Protein IDBP-372661.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2
Protein Name coagulation factor II (thrombin)
Synonyms PT; RPRGL2; THPH1;
Species Homo sapiens
Ensembl Protein ENSP00000387413
InnateDB Gene IDBG-42048 (F2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000001 Kringle
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR013806 Kringle-like fold
IPR018992 Thrombin light chain
PFAM PF00051
PF00594
PF09396
PRINTS PR00001
PIRSF
SMART SM00130
SM00069
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL C9JV37
UniProt Splice Variant
Entrez Gene 2147
UniGene Hs.696214
RefSeq
HUGO HGNC:3535
OMIM 176930
CCDS
HPRD 01488
IMGT
EMBL AC115088
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca