Version 5.4
Homo sapiens Protein: LRRCC1
Summary
InnateDB Protein IDBP-372997.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRCC1
Protein Name leucine rich repeat and coiled-coil domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000394695
InnateDB Gene IDBG-27023 (LRRCC1)
Protein Structure
UniProt Annotation
Function Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. {ECO:0000269PubMed:18728398}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:18728398}. Note=Associates with the centrosome throughout the cell cycle and extensively accumulates during the mitotic phase.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR009053 Prefoldin
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C099
PhosphoSite PhosphoSite-Q9C099
TrEMBL
UniProt Splice Variant
Entrez Gene 85444
UniGene Hs.193115
RefSeq XP_005251375
HUGO HGNC:29373
OMIM
CCDS
HPRD 11160
IMGT
EMBL AB051551 AC011773 AC083962 AK056185 AK057990 AK302648 BC030701 BR000818 CH471068
GenPept AAH30701 BAB21855 BAB71115 BAB71626 BAG63888 EAW87121 FAA00427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca