InnateDB Protein
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IDBP-373054.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNPO2
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Protein Name
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transportin 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000397379
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InnateDB Gene
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IDBG-30800 (TNPO2)
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Protein Structure
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Function |
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000357
HEAT
IPR001494
Importin-beta, N-terminal domain
IPR016024
Armadillo-type fold
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PFAM |
PF02985
PF03810
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PRINTS |
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PIRSF |
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SMART |
SM00913
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TIGRFAMs |
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Modification |
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SwissProt |
O14787
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PhosphoSite |
PhosphoSite-O14787
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TrEMBL |
Q4LE60
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UniProt Splice Variant |
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Entrez Gene |
30000
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UniGene |
Hs.714402
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RefSeq |
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HUGO |
HGNC:19998
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OMIM |
603002
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CCDS |
CCDS45992
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HPRD |
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IMGT |
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EMBL |
AB210011
AC018761
AF007748
AF019039
BC072420
CH471106
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GenPept |
AAB71349
AAB83973
AAH72420
BAE06093
EAW84300
EAW84301
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