InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLAC8

Summary

InnateDB Protein

IDBP-373186.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAC8

Protein Name

placenta-specific 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000399700

InnateDB Gene

IDBG-27607 (PLAC8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0009409	response to cold
GO:0040015	negative regulation of multicellular organism growth
GO:0042742	defense response to bacterium
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050873	brown fat cell differentiation