Version 5.4
Homo sapiens Protein: SLC48A1
Summary
InnateDB Protein IDBP-373362.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC48A1
Protein Name solute carrier family 48 (heme transporter), member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000415998
InnateDB Gene IDBG-29040 (SLC48A1)
Protein Structure
UniProt Annotation
Function Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. {ECO:0000269PubMed:18418376}.
Subcellular Localization Endosome membrane {ECO:0000269PubMed:18418376}; Multi-pass membrane protein {ECO:0000269PubMed:18418376}. Lysosome membrane {ECO:0000269PubMed:18418376}; Multi-pass membrane protein {ECO:0000269PubMed:18418376}.
Disease Associations
Tissue Specificity Highly expressed in the brain, kidney, heart and skeletal muscle. Moderately expressed in the liver, lung, placenta and small intestine. {ECO:0000269PubMed:18418376}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015232 heme transporter activity
Biological Process
GO:0015886 heme transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1K1
PhosphoSite PhosphoSite-
TrEMBL F8VQX9
UniProt Splice Variant
Entrez Gene 55652
UniGene Hs.438867
RefSeq NP_060312
HUGO HGNC:26035
OMIM 612187
CCDS CCDS8755
HPRD 07916
IMGT
EMBL AC004241 AC004466 AC137054 AK000496 BC002759 BC026344 BC065033 CH471111
GenPept AAH02759 AAH26344 AAH65033 BAA91205 EAW57951

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca