InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C2

Summary

InnateDB Protein

IDBP-373403.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

complement component 2

Synonyms

ARMD14; CO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000395683

InnateDB Gene

IDBG-124824 (C2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006956	complement activation
GO:0006958	complement activation, classical pathway
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)
GO:2000427	positive regulation of apoptotic cell clearance

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002035 von Willebrand factor, type A
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR011360 Complement B/C2

PFAM

PF00084
PF00089
PF00092

PRINTS

PR00722

PIRSF

PIRSF001154

SMART

SM00032
SM00020
SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References