InnateDB Protein
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IDBP-37349.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MCC
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Protein Name
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mutated in colorectal cancers
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Synonyms
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MCC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305617
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InnateDB Gene
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IDBG-37345 (MCC)
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Protein Structure
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Function |
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. {ECO:0000269PubMed:18591935, ECO:0000269PubMed:19555689, ECO:0000269PubMed:22480440}.
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Subcellular Localization |
Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
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Disease Associations |
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Tissue Specificity |
Expressed in a variety of tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
52
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007165
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signal transduction
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GO:0010633
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negative regulation of epithelial cell migration
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GO:0016055
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Wnt signaling pathway
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GO:0050680
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negative regulation of epithelial cell proliferation
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR010978
tRNA-binding arm
IPR019536
Usher syndrome type-1C protein-binding protein 1, PDZ domain
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PFAM |
PF10506
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P23508
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PhosphoSite |
PhosphoSite-P23508
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TrEMBL |
D6REY2
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UniProt Splice Variant |
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Entrez Gene |
4163
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UniGene |
Hs.593171
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RefSeq |
NP_002378
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HUGO |
HGNC:6935
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OMIM |
159350
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CCDS |
CCDS4111
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HPRD |
01157
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IMGT |
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EMBL |
AC008536
AC010431
AC079465
AC093208
AC106750
AC126917
AK128596
BC009279
BC018919
CH471086
M62397
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GenPept |
AAA52069
AAH09279
AAH18919
BAC87521
EAW48984
EAW48986
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