InnateDB Protein
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IDBP-373580.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HDAC7
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Protein Name
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histone deacetylase 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000404394
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InnateDB Gene
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IDBG-29060 (HDAC7)
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Protein Structure
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Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. {ECO:0000250, ECO:0000269PubMed:12239305}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
149
[view]
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Protein-Protein |
85
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
62
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004407
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histone deacetylase activity
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GO:0005080
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protein kinase C binding
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GO:0005515
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protein binding
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GO:0019901
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protein kinase binding
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GO:0032041
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NAD-dependent histone deacetylase activity (H3-K14 specific)
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GO:0033613
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activating transcription factor binding
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GO:0046872
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metal ion binding
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GO:0046969
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NAD-dependent histone deacetylase activity (H3-K9 specific)
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GO:0046970
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NAD-dependent histone deacetylase activity (H4-K16 specific)
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GO:0070491
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repressing transcription factor binding
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GO:0071889
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14-3-3 protein binding
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GO:0097372
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NAD-dependent histone deacetylase activity (H3-K18 specific)
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000286
Histone deacetylase superfamily
IPR017320
Histone deacetylase class II, eukaryotic
IPR023801
Histone deacetylase domain
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PFAM |
PF00850
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PRINTS |
PR01270
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PIRSF |
PIRSF037911
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WUI4
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PhosphoSite |
PhosphoSite-Q8WUI4
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TrEMBL |
F8VWY3
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UniProt Splice Variant |
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Entrez Gene |
51564
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UniGene |
Hs.709475
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RefSeq |
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HUGO |
HGNC:14067
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OMIM |
606542
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CCDS |
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HPRD |
09133
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IMGT |
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EMBL |
AC004466
AF239243
AK001032
AK001190
AK024469
AK027781
AK122588
AK128383
AK299292
AK301545
AK303481
AL117455
AY302468
AY321367
BC006453
BC020505
BC064840
BT009771
CH471111
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GenPept |
AAF63491
AAH06453
AAH20505
AAH64840
AAP84704
AAP88773
AAQ18232
BAA91474
BAA91545
BAB15759
BAB55363
BAC56929
BAG54670
BAG61307
BAG63042
BAG64517
CAB55935
EAW57957
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