InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN13

Summary

InnateDB Protein

IDBP-373812.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN13

Protein Name

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

Synonyms

FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE;

Species

Homo sapiens

Ensembl Protein

ENSP00000394794

InnateDB Gene

IDBG-28517 (PTPN13)

Protein Structure

UniProt Annotation

Function

Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. {ECO:0000269PubMed:15611135}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269PubMed:11356191}. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover.

Disease Associations

Tissue Specificity

Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	34 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0043005	neuron projection
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001478 PDZ domain
IPR003100 PAZ domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR011019 KIND
IPR012153 Protein-tyrosine phosphatase, non-receptor type-13
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM