InnateDB Protein
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IDBP-373837.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ESRP1
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Protein Name
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epithelial splicing regulatory protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000405738
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InnateDB Gene
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IDBG-29026 (ESRP1)
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Protein Structure
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Function |
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269PubMed:19285943}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:19285943}.
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Disease Associations |
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Tissue Specificity |
Epithelial cell-specific. {ECO:0000269PubMed:19285943}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR012337
Ribonuclease H-like domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NXG1
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PhosphoSite |
PhosphoSite-Q6NXG1
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TrEMBL |
E5RI26
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UniProt Splice Variant |
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Entrez Gene |
54845
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UniGene |
Hs.602923
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RefSeq |
NP_060167
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HUGO |
HGNC:25966
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OMIM |
612959
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CCDS |
CCDS47897
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HPRD |
07881
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IMGT |
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EMBL |
AC108860
AK000178
AP005660
BC019932
BC067098
BC099916
BC112043
BX647570
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GenPept |
AAH19932
AAH67098
AAH99916
AAI12044
BAA90992
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