Version 5.4
Homo sapiens Protein: APOBR
Summary
InnateDB Protein IDBP-373942.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBR
Protein Name apolipoprotein B receptor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000416094
InnateDB Gene IDBG-22787 (APOBR)
Protein Structure
UniProt Annotation
Function Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269PubMed:10852956, ECO:0000269PubMed:15591219, ECO:0000269PubMed:9633939}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:10191299, ECO:0000269PubMed:7619811}; Peripheral membrane protein {ECO:0000269PubMed:10191299, ECO:0000269PubMed:7619811}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
Disease Associations
Tissue Specificity Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells. {ECO:0000269PubMed:10191299, ECO:0000269PubMed:10852956}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006869 lipid transport
GO:0006898 receptor-mediated endocytosis
GO:0008203 cholesterol metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0042627 chylomicron
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VD83
PhosphoSite PhosphoSite-Q0VD83
TrEMBL
UniProt Splice Variant
Entrez Gene 55911
UniGene Hs.200333
RefSeq
HUGO HGNC:24087
OMIM 605220
CCDS
HPRD 05561
IMGT
EMBL AC138894 AF141332 AF141333 AK075085 BC119786 BC119788
GenPept AAF76255 AAF76256 AAI19787 AAI19789

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca