Version 5.4
Homo sapiens Protein: TCF23
Summary
InnateDB Protein IDBP-37396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF23
Protein Name transcription factor 23
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296096
InnateDB Gene IDBG-37394 (TCF23)
Protein Structure
UniProt Annotation
Function Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity Expressed in liver, kidney and spleen. {ECO:0000269PubMed:14516699}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046983 protein dimerization activity
Biological Process
GO:0007517 muscle organ development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7RTU1
PhosphoSite PhosphoSite-Q7RTU1
TrEMBL
UniProt Splice Variant
Entrez Gene 150921
UniGene Hs.591583
RefSeq NP_786951
HUGO HGNC:18602
OMIM 609635
CCDS CCDS33163
HPRD 18734
IMGT
EMBL AC013403 BC137191 BC137192 BK000143
GenPept AAI37192 AAI37193 DAA00305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca