Version 5.4
Homo sapiens Protein: TRAF4
Summary
InnateDB Protein IDBP-374001.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF4
Protein Name TNF receptor-associated factor 4
Synonyms CART1; MLN62; RNF83;
Species Homo sapiens
Ensembl Protein ENSP00000415789
InnateDB Gene IDBG-37645 (TRAF4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 90 [view]
Protein-Protein 89 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0016567 protein ubiquitination
GO:0046330 positive regulation of JNK cascade
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001293 Zinc finger, TRAF-type
IPR001841 Zinc finger, RING-type
IPR008974 TRAF-like
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL K7EJG7
UniProt Splice Variant
Entrez Gene 9618
UniGene Hs.8375
RefSeq
HUGO HGNC:12034
OMIM 602464
CCDS
HPRD 03915
IMGT
EMBL AC010761
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca