Version 5.4
Homo sapiens Protein: ALAS2
Summary
InnateDB Protein IDBP-374002.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALAS2
Protein Name aminolevulinate, delta-, synthase 2
Synonyms ALAS-E; ALASE; ANH1; ASB; XLDPP; XLEPP; XLSA;
Species Homo sapiens
Ensembl Protein ENSP00000407204
InnateDB Gene IDBG-72056 (ALAS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003870 5-aminolevulinate synthase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006778 porphyrin-containing compound metabolic process
GO:0009058 biosynthetic process
Cellular Component
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR004839 Aminotransferase, class I/classII
IPR015118 5-aminolevulinate synthase presequence
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00155
PF09029
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 212
UniGene Hs.522666
RefSeq
HUGO HGNC:397
OMIM 301300
CCDS
HPRD 02356
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca