InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53INP1

Summary

InnateDB Protein

IDBP-374013.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53INP1

Protein Name

tumor protein p53 inducible nuclear protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000390063

InnateDB Gene

IDBG-29246 (TP53INP1)

Protein Structure

UniProt Annotation

Function

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269PubMed:11511362, ECO:0000269PubMed:22421968, ECO:0000269PubMed:22470510}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11511362, ECO:0000269PubMed:12067065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016209	antioxidant activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0010508	positive regulation of autophagy
GO:0030336	negative regulation of cell migration
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048102	autophagic cell death