InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC5A5

Summary

InnateDB Protein

IDBP-37421.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC5A5

Protein Name

solute carrier family 5 (sodium iodide symporter), member 5

Synonyms

NIS; TDH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000222248

InnateDB Gene

IDBG-37419 (SLC5A5)

Protein Structure

UniProt Annotation

Function

Mediates iodide uptake in the thyroid gland.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. {ECO:0000269PubMed:10487695, ECO:0000269PubMed:9171822, ECO:0000269PubMed:9486973, ECO:0000269PubMed:9745458}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. {ECO:0000269PubMed:8806637, ECO:0000269PubMed:9329364}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008507	sodium:iodide symporter activity
GO:0015111	iodide transmembrane transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006590	thyroid hormone generation
GO:0006810	transport
GO:0006811	ion transport
GO:0015705	iodide transport
GO:0034641	cellular nitrogen compound metabolic process
GO:0035725	sodium ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus