InnateDB Protein
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IDBP-374224.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RMI1
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Protein Name
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RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402433
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InnateDB Gene
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IDBG-74108 (RMI1)
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Protein Structure
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Function |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269PubMed:15775963, ECO:0000269PubMed:16537486, ECO:0000269PubMed:16595695}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15775963}. Note=Forms foci in response to DNA damage.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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PDB ID |
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InterPro |
IPR013894
Domain of unknown function DUF1767
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PFAM |
PF08585
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q9H9A7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80010
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UniGene |
Hs.726327
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RefSeq |
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HUGO |
HGNC:25764
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OMIM |
610404
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CCDS |
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HPRD |
09867
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IMGT |
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EMBL |
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GenPept |
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