Version 5.4
Homo sapiens Protein: GPR20
Summary
InnateDB Protein IDBP-37424.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR20
Protein Name G protein-coupled receptor 20
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366970
InnateDB Gene IDBG-37422 (GPR20)
Protein Structure
UniProt Annotation
Function Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. {ECO:0000269PubMed:18347022}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:18347022}; Multi-pass membrane protein {ECO:0000269PubMed:18347022}.
Disease Associations
Tissue Specificity Ubiquitous with highest levels in intestinal tissues. In the brain detected in thalamus, putamen, and caudate, but not in frontal cortex, pons and hypothalamus. {ECO:0000269PubMed:18347022}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99678
PhosphoSite PhosphoSite-Q99678
TrEMBL Q59GP3
UniProt Splice Variant
Entrez Gene 2843
UniGene Hs.188859
RefSeq NP_005284
HUGO HGNC:4475
OMIM 601908
CCDS CCDS34949
HPRD 03550
IMGT
EMBL AB209066 BC117409 CH471060 U66579
GenPept AAC51302 AAI17410 BAD92303 EAW92227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca