Version 5.4
Homo sapiens Protein: CLEC17A
Summary
InnateDB Protein IDBP-374241.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC17A
Protein Name C-type lectin domain family 17, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393719
InnateDB Gene IDBG-33576 (CLEC17A)
Protein Structure
UniProt Annotation
Function Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues. {ECO:0000269PubMed:19419970}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269PubMed:19419970}.
Disease Associations
Tissue Specificity Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen. {ECO:0000269PubMed:19419970}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0042806 fucose binding
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZS10
PhosphoSite PhosphoSite-Q6ZS10
TrEMBL
UniProt Splice Variant
Entrez Gene 388512
UniGene Hs.567933
RefSeq NP_001191047
HUGO HGNC:34520
OMIM
CCDS CCDS56087
HPRD 16993
IMGT
EMBL AC010527 AC140008 AK127809 BC140848 BC144665 CH471106
GenPept AAI40849 AAI44666 BAC87146 EAW84437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca