Version 5.4
Homo sapiens Protein: CDCP1
Summary
InnateDB Protein IDBP-374255.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCP1
Protein Name CUB domain containing protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000399342
InnateDB Gene IDBG-29480 (CDCP1)
Protein Structure
UniProt Annotation
Function May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269PubMed:11466621, ECO:0000269PubMed:12799299, ECO:0000269PubMed:15153610, ECO:0000269PubMed:16007225, ECO:0000269PubMed:16404722, ECO:0000269PubMed:8647901}.
Subcellular Localization Isoform 1: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide.Isoform 3: Secreted.
Disease Associations
Tissue Specificity Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. {ECO:0000269PubMed:11466621, ECO:0000269PubMed:12660814, ECO:0000269PubMed:15153610, ECO:0000269PubMed:16007225}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
PFAM PF00431
PRINTS
PIRSF
SMART SM00042
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H5V8
PhosphoSite PhosphoSite-Q9H5V8
TrEMBL
UniProt Splice Variant
Entrez Gene 64866
UniGene Hs.611520
RefSeq NP_835488
HUGO HGNC:24357
OMIM 611735
CCDS CCDS46812
HPRD 16696
IMGT
EMBL AC104165 AC105902 AF468010 AK023834 AK026187 AK026622 AY026461 AY167484 AY358779 AY375452 BC021099 BC069254
GenPept AAH21099 AAH69254 AAK02058 AAO33397 AAO34538 AAQ89139 AAR21289 BAB14695 BAB15388 BAB15511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca