InnateDB Protein
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IDBP-374296.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OGDH
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Protein Name
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oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
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Synonyms
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AKGDH; E1k; OGDC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388084
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InnateDB Gene
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IDBG-15045 (OGDH)
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Protein Structure
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Function |
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
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Subcellular Localization |
Mitochondrion matrix.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004591
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oxoglutarate dehydrogenase (succinyl-transferring) activity
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GO:0016624
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oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
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GO:0030976
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thiamine pyrophosphate binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001017
Dehydrogenase, E1 component
IPR029061
Thiamin diphosphate-binding fold
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PFAM |
PF00676
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q02218
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PhosphoSite |
PhosphoSite-Q02218
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TrEMBL |
C9J4G7
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UniProt Splice Variant |
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Entrez Gene |
4967
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UniGene |
Hs.488181
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RefSeq |
NP_001003941
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HUGO |
HGNC:8124
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OMIM |
613022
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CCDS |
CCDS47580
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HPRD |
08938
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IMGT |
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EMBL |
AC004859
AC011894
AK304439
BC004964
BC009580
BC014617
CH471128
D10523
D32064
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GenPept |
AAH04964
AAH09580
AAH14617
AAQ96884
AAQ96885
BAA01393
BAA06836
BAG65261
EAW61086
EAW61087
EAW61089
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