InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBFOX2

Summary

InnateDB Protein

IDBP-374387.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBFOX2

Protein Name

RNA binding protein, fox-1 homolog (C. elegans) 2

Synonyms

dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2; HRNBP2; RBM9; RTA;

Species

Homo sapiens

Ensembl Protein

ENSP00000407855

InnateDB Gene

IDBG-5580 (RBFOX2)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. {ECO:0000250, ECO:0000269PubMed:11875103}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0016070	RNA metabolic process
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0043484	regulation of RNA splicing
GO:0045892	negative regulation of transcription, DNA-templated