InnateDB Protein
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IDBP-374417.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HEPH
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Protein Name
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hephaestin
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Synonyms
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CPL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000411687
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InnateDB Gene
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IDBG-73560 (HEPH)
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Protein Structure
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Function |
May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Detected in breast, colon, bone trabecular cells and fibroblasts.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008972
Cupredoxin
IPR011706
Multicopper oxidase, type 2
IPR011707
Multicopper oxidase, type 3
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PFAM |
PF07731
PF07732
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BQS7
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PhosphoSite |
PhosphoSite-Q9BQS7
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TrEMBL |
Q5JZ07
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UniProt Splice Variant |
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Entrez Gene |
9843
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UniGene |
Hs.31720
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RefSeq |
NP_001124332
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HUGO |
HGNC:4866
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OMIM |
300167
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CCDS |
CCDS48133
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HPRD |
02159
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IMGT |
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EMBL |
AB014598
AF148860
AJ296162
AL030998
AL157698
AY358990
BC011561
CH471132
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GenPept |
AAH11561
AAK08131
AAQ89349
BAA31673
CAC35365
EAX05384
EAX05385
EAX05386
EAX05388
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