InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR2

Summary

InnateDB Protein

IDBP-374487.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR2

Protein Name

chemokine (C-C motif) receptor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000399285

InnateDB Gene

IDBG-30182 (CCR2)

Protein Structure

UniProt Annotation

Function

Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269PubMed:23408426}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18587271}; Multi-pass membrane protein {ECO:0000269PubMed:18587271}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016493	C-C chemokine receptor activity
GO:0031727	CCR2 chemokine receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0002407	dendritic cell chemotaxis
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002829	negative regulation of type 2 immune response
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007259	JAK-STAT cascade
GO:0009611	response to wounding
GO:0010574	regulation of vascular endothelial growth factor production
GO:0010820	positive regulation of T cell chemotaxis
GO:0016032	viral process
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0019725	cellular homeostasis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0035705	T-helper 17 cell chemotaxis
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043310	negative regulation of eosinophil degranulation
GO:0045087	innate immune response
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0050870	positive regulation of T cell activation
GO:0070098	chemokine-mediated signaling pathway
GO:0090026	positive regulation of monocyte chemotaxis
GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages
GO:2000439	positive regulation of monocyte extravasation
GO:2000451	positive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464	positive regulation of astrocyte chemotaxis
GO:2000473	positive regulation of hematopoietic stem cell migration

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR002237 CC chemokine receptor 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR01107

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P41597