InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR5

Summary

InnateDB Protein

IDBP-374504.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR5

Protein Name

chemokine (C-C motif) receptor 5

Synonyms

CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22;

Species

Homo sapiens

Ensembl Protein

ENSP00000404881

InnateDB Gene

IDBG-30229 (CCR5)

Protein Structure

UniProt Annotation

Function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. {ECO:0000269PubMed:11323418, ECO:0000269PubMed:8639485, ECO:0000269PubMed:8649511, ECO:0000269PubMed:8649512, ECO:0000269PubMed:8663314, ECO:0000269PubMed:8699119}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11323418}; Multi-pass membrane protein {ECO:0000269PubMed:11323418}.

Disease Associations

Diabetes mellitus, insulin-dependent, 22 (IDDM22) [MIM:612522]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:19073967}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. {ECO:0000269PubMed:8639485, ECO:0000269PubMed:8663314}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding
GO:0071791	chemokine (C-C motif) ligand 5 binding

Biological Process

GO:0000165	MAPK cascade
GO:0002407	dendritic cell chemotaxis
GO:0006816	calcium ion transport
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016032	viral process
GO:0019722	calcium-mediated signaling
GO:0023052	signaling
GO:0030260	entry into host cell
GO:0070098	chemokine-mediated signaling pathway
GO:0070723	response to cholesterol
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR002236 CC chemokine receptor 1
IPR002240 CC chemokine receptor 5
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00241
PR00237
PR00657
PR01106
PR01110

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51681