InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JDP2

Summary

InnateDB Protein

IDBP-374512.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JDP2

Protein Name

Jun dimerization protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000399587

InnateDB Gene

IDBG-13003 (JDP2)

Protein Structure

UniProt Annotation

Function

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269PubMed:12707301, ECO:0000269PubMed:12903123, ECO:0000269PubMed:16026868, ECO:0000269PubMed:16518400}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding