InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMPR1B

Summary

InnateDB Protein

IDBP-374579.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMPR1B

Protein Name

bone morphogenetic protein receptor, type IB

Synonyms

ALK-6; ALK6; CDw293;

Species

Homo sapiens

Ensembl Protein

ENSP00000401907

InnateDB Gene

IDBG-30667 (BMPR1B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 132 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	132 [view]
Protein-Protein	132 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046332	SMAD binding
GO:0046872	metal ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001502	cartilage condensation
GO:0001550	ovarian cumulus expansion
GO:0001654	eye development
GO:0002062	chondrocyte differentiation
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009953	dorsal/ventral pattern formation
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0031290	retinal ganglion cell axon guidance
GO:0035108	limb morphogenesis
GO:0042698	ovulation cycle
GO:0043010	camera-type eye development
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0060041	retina development in camera-type eye
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000333 Ser/Thr protein kinase, TGFB receptor
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714
PF08515

PRINTS

PR00653
PR00109

PIRSF

SMART

SM00220
SM00467
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt