InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DIS3

Summary

InnateDB Protein

IDBP-37466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIS3

Protein Name

DIS3 mitotic control homolog (S. cerevisiae)

Synonyms

2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44;

Species

Homo sapiens

Ensembl Protein

ENSP00000366997

InnateDB Gene

IDBG-37462 (DIS3)

Protein Structure

UniProt Annotation

Function

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269PubMed:19056938, ECO:0000269PubMed:20531386}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364	rRNA processing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0043547	positive regulation of GTPase activity
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071034	CUT catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane