Version 5.4
Homo sapiens Protein: NREP
Summary
InnateDB Protein IDBP-374662.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NREP
Protein Name chromosome 5 open reading frame 13
Synonyms C5orf13; D4S114; P311; PRO1873; PTZ17; SEZ17;
Species Homo sapiens
Ensembl Protein ENSP00000402965
InnateDB Gene IDBG-36834 (NREP)
Protein Structure
UniProt Annotation
Function May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269PubMed:11358844, ECO:0000269PubMed:16229809}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11358844}.
Disease Associations
Tissue Specificity Expressed in lung (at protein level). {ECO:0000269PubMed:16484684}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR024417 Neuronal protein 3.1
PFAM PF11092
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16612
PhosphoSite PhosphoSite-Q16612
TrEMBL D6RIC9
UniProt Splice Variant
Entrez Gene 9315
UniGene Hs.738960
RefSeq NP_001135954
HUGO HGNC:16834
OMIM 607332
CCDS CCDS4105
HPRD 09545
IMGT
EMBL AC022108 AC025182 AC025450 AC114297 AK298779 AK315617 BC011050 BC019068 BC072013 BC072443 CH471086 U30521 U36189
GenPept AAA74903 AAA93255 AAH11050 AAH19068 AAH72013 AAH72443 BAG37985 BAH12868 EAW49019 EAW49020 EAW49021 EAW49023 EAW49025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca